Prior small reports have postulated a link between gastrointestinal polyposis and childhood and young adulthood cancer (CYAC) treatment (therapy-associated polyposis; TAP), but this remains a poorly understood phenomenon. The aim of this study from HIP Investigator Dr. Jennifer Weiss was to describe the phenotypic spectrum of TAP in a multi-institutional cohort.
In this multi-institutional study, researchers present 34 patients with TAP, an apparently acquired gastrointestinal polyposis phenomenon manifesting years after chemotherapy and/or radiotherapy exposure. This series demonstrates that TAP should be considered in patients with significant polyposis, no known pathologic germline variant and/or family history of gastrointestinal neoplasia, and a history of prior CYAC treatment.
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