Macular retinal nerve fibre layer and ganglion cell-inner plexiform layer thicknesses are reported to vary across age, gender and racial/ethnic groups. The aim of this study including HIP Investigator Dr. Yao Liu was to determine whether macular retinal nerve fibre layer (mRNFL) and ganglion cell-inner plexiform layer (GC-IPL) thicknesses vary by ethnicity after accounting for total retinal thickness.
20237 participants from the UK Biobank cohort who underwent macula-centred spectral domain-optical coherence tomography scans were analyzed. This study suggests that using layer thickness ratio (retinal layer thicknesses/total retinal thickness) rather than absolute thickness values when comparing retinal layer thicknesses across groups is beneficial.
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