Dr. Noelle LoConte et al. sought to identify clinical and non-clinical factors which were associated with the development of dose-limiting toxicity in phase I studies. Over 200 charts were reviewed from 24 cytotoxic chemotherapy studies and Cumulative Illness Rating Score-Geriatrics (CIRS-G) score was not associated with dose-limiting toxicity. Several social and clinical factors may predict for development of dose-limiting toxicity.
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