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A robust approach to sample size calculation in cancer immunotherapy trials with delayed treatment effect

A robust approach to sample size calculation in cancer immunotherapy trials with delayed treatment effect

A group of authors including HIP Investigator, Dr. Menggang Yu et al. presents an approach to calculate sample size based on a maximin efficiency robust test. Both theoretical derivations and simulation results show the proposed approach can guarantee the desired power in worst case scenarios and often much more efficient than existing approaches. Application to a real trial design is also illustrated.

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